Two precise, simple, accurate, reproducible, rapid and economical UV spectrophotometric methods have been developed for simultaneous estimation of montelukast and doxofylline in tablet dosage form by using distilled water as solvent. Method I is based on formation and solving of simultaneous equation method, known as vierodt’s method. Montelukast and doxofylline show absorbance maxima at 283 nm and 274 nm respectively, so absorbance was measured at the same wavelength for the estimation of montelukast and doxofylline in tablet combination. Method II is based on principle of Q-analysis, known as absorbance ratio method. Absorbance was measured at 285 nm (isobestic point) and 274 nm (λmax of doxofylline). Montelukast and doxofylline obeys beer’s law in the concentration range of 5 to 30 µg/ml. Percentage estimation of montelukast and doxofylline in tablet dosage form by method I is 99 and 99.85 and by method II is 99 and 99.89 respectively with standard deviation ≤2. Methods are validated according to ICH guidelines and can be applied for routine analysis of drugs in tablet dosage form.
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